Single-session combined therapy with chemoembolization and DSA-CT guided radiofrequency ablation in hepatocellular carcinoma larger than 5 cm: A primary clinical study

doi:10.3877/cma.j.issn.2095-5782.2014.02.004

Abstract

Abstract:

Objective

To assess the safety and efficacy of single-session combined therapy with transcatheter arterial chemoembolization (TACE) and DSA-CT guided radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) larger than 5 cm.

Methods

A total of 21 patients were treated with TACE immediately followed by DSA-CT-guided RFA. Rate of technical success, local-regional tumor response, recurrence-free survival time, survival rate and complications were evaluated at follow-up images and AFP (α-fetoprotein).

Results

Technical success was achieved in all 25 visible HCC. No major complications was observed in any patient. Nineteen patients were complete response (CR) and 2 were partial response (PR) after the 1st months. Coagulation necrosis was the major appearance. CR occupied 90.48% (19/21). PR occupied 9.52% (2/21). Local-regional tumor response in solitary nodular lesions (17/17, 100%) was superior to multiple nodular lesions (2/4, 50.00%; P=0.034). During follow-up period, mean recurrence-free survival time was 11.8±6.0 months in 19 cases with CR. The estimated overall survival rate at 6, 12 months and 18 months was 100%.

Conclusions

Single-session combined therapy with TACE and DSA-CT guided RFA in large hepatocellular carcinoma was safe and effective, especially for solitary nodular lesions.

Key words: Carcinoma, hepatocellular, Chemoembolization, therapeutic, Catheter ablation, Single-session

Zhijun Wang, Maoqiang Wang, Feng Duan, Peng Song, Fengyong Liu, Yan Wang, Jieyu Yan, Kai Li. Single-session combined therapy with chemoembolization and DSA-CT guided radiofrequency ablation in hepatocellular carcinoma larger than 5 cm: A primary clinical study[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2014, 02(02): 13-18.

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References 22

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参数		数值
年龄[范围（平均），岁]		38~67（48.3±9.4）
性别[例（%）]		?
?	男性	17（81%）
?	女性	4（19%）
Child–Pugh分级[例（%）]		?
?	A	16（76%）
?	B	5（24%）
肝硬化病因[例（%）]		?
?	乙肝	14（67%）
?	丙肝	5（23%）
?	乙肝合并丙肝	2（10%）
甲胎蛋白（ng/ml）[例（%）]		?
?	≤20	8（38%）
?	>20	13（62%）
病灶部位[例（%）]		?
?	近膈下	9 （43%）
?	非膈下	16 （57%）
最大直径[例（%）]		?
?	5~10 cm	16（57%）
?	>10 cm	9（43%）
病灶个数		?
?	1个	17
?	2个	4
既往TACE情况（例）		?
?	1次	10
?	2次	6
?	3次	3
?	4次	2

参数		数值
年龄[范围（平均），岁]		38~67（48.3±9.4）
性别[例（%）]		?
?	男性	17（81%）
?	女性	4（19%）
Child–Pugh分级[例（%）]		?
?	A	16（76%）
?	B	5（24%）
肝硬化病因[例（%）]		?
?	乙肝	14（67%）
?	丙肝	5（23%）
?	乙肝合并丙肝	2（10%）
甲胎蛋白（ng/ml）[例（%）]		?
?	≤20	8（38%）
?	>20	13（62%）
病灶部位[例（%）]		?
?	近膈下	9 （43%）
?	非膈下	16 （57%）
最大直径[例（%）]		?
?	5~10 cm	16（57%）
?	>10 cm	9（43%）
病灶个数		?
?	1个	17
?	2个	4
既往TACE情况（例）		?
?	1次	10
?	2次	6
?	3次	3
?	4次	2

病灶类型	肿瘤彻底灭活能力		合计
病灶类型	CR	PR	合计
单结节型	17	0	17
多结节型	2	2	4
合计	19	2	21

病灶类型	肿瘤彻底灭活能力		合计
病灶类型	CR	PR	合计
单结节型	17	0	17
多结节型	2	2	4
合计	19	2	21

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