Abstract:
Objective
To investigate the expression and significance of hypox-inducible factor 1 alpha subunit（HIF-1 α）and Foxp3 in the residual tumor tissues of hepatocellular carcinoma（HCC）after transcatheter arterial chemoembolization（TACE）.
Methods
The surgical specimens of HCC after TACE were colleted in 31 cases（TACE group），and surgical specimens of HCC without having received any other treatment were obtained in 37 cases（pure surgery group）.The expression of HIF-1α and Foxp3 in the residual tumor tissues was determined by using immuno-histochemical SP method.
Results
The positive expression of HIF-1α and Foxp3 in TACE group（90.32%，87.10%）were higher than those in direct surgery group（62.16%，59.50%，P=0.008，0.012）.For the residual cancerous tissues of TACE group，the positive expression of HIF-1α was positively correlated with Foxp3（r=0.537，P=0.006）.
Conclusions
Significant overexpression of HIF-1α and Foxp3 is found in patients with HCC after TACE，and enhances the immune suppression of local tumor.which may be one of causes of recurrence and metastasis of HCC after TACE.
Key words:
Carcinoma，hepatocellular,
Chemoembolization，therapeutic,
Hypox-idnciucible factor 1，alpha subunit
Hao Song, Youtao Yu, Dongfeng He, Qian Li. Expression and significance of HIF-1α and Foxp3 in hepatocellular carcinoma after transcatheter arterial chemoembolization[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2013, 01(02): 7-10.