Inter ventional treatment for acute ischemia stroke：the latest international research result and national 973 research program of "MODIFIED" trial

doi:10.3877/cma.j.issn.2095-5782.2013.01.017

Chinese Journal of Interventional Radiology(Electronic Edition) ›› 2013, Vol. 01 ›› Issue (01): 60-62. doi: 10.3877/cma.j.issn.2095-5782.2013.01.017

• Featured Research Design • Previous Articles

Inter ventional treatment for acute ischemia stroke：the latest international research result and national 973 research program of "MODIFIED" trial

Wei-jian JIANG

Received:2013-06-22 Online:2013-08-01 Published:2024-12-02

Abstract

Wei-jian JIANG. Inter ventional treatment for acute ischemia stroke：the latest international research result and national 973 research program of "MODIFIED" trial[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2013, 01(01): 60-62.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhjrfsxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5782.2013.01.017

https://zhjrfsxdzzz.cma-cmc.com.cn/EN/Y2013/V01/I01/60

Figures/Tables 1

References 8

1	The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.Tissue plasminogen activator for acute ischemic stroke.N Engl J Med，1995，333（24）：1581-1587.
2	Furlan A，Higashida R，Wechsler L，et al.Intra-arterial prourokinase for acute ischemic stroke.The PROACT Ⅱ study：a randomized controlled trial.Prolyse in Acute Cerebral Thromboembolism.JAMA，1999，282（21）：2003-2011.
3	Hacke W，Kaste M，Bluhmki E，et al.Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.N Engl J Med，2008，359（13）：1317-1329.
4	Smith WS，Sung G，Starkman S，et al.Safety and efficacy of mechanical embolectomy in acute ischemic stroke：results of the MERCI trial.Stroke，2005，36（7）：1432-1438.
5	Penumbra Pivotal Stroke Trial Investigators.The penumbra pivotal stroke trial：safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease.Stroke，2009，40（8）：2761-2768.
6	Broderick JP，Palesch YY，Demchuk AM，et al.Endovascular therapy after intravenous t-PA versus t-PA alone for stroke.N Engl J Med，2013，368（10）：893-903.
7	Ciccone A，Valvassori L，Nichelatti M，et al.Endovascular treatment for acute ischemic stroke.N Engl J Med，2013，368（10）：904-913.
8	Kidwell CS，Jahan R，Gornbein J，et al.A trial of imagingselection and endovascular treatment for ischemic stroke.N Engl J Med，2013，368（10）：914-923.

试验	IMS Ⅲ	SYNTHESIS Expansion	MR RESCUE
患者例数/参与医院家数	656/58	362/24	127/22
研究起止年份	2006—2012	2008—2012	2004—2011
患者重要特征	AIS 3 h内；NIHSS≥10，或NIHSS 8～9但有CTA证实的动脉闭塞；在有急诊CTA的306例患者中，动脉闭塞占92%	AIS 4.5 h内；对NISHH没有要求；无动脉闭塞患者的百分率数据	AIS 8 h内；NIHSS6～29；所有患者均有前循环动脉闭塞证据；58%患者有半暗带
试验组介入诊治时间要求	无	无	无
试验组血管内治疗方法	动脉溶栓，Merci、Penumbra、Solitaire FR装置取栓	动脉溶栓，Merci、Penumbra、SolitaireFR、Trevo装置取栓	Merci、Penumbra装置取栓
试验组早期再通（TICI）	2a～3级：65%～81%；2b～3级：23%～44%	无可用数据	2a～3级：67%；2b～3级：无数据

试验	IMS Ⅲ	SYNTHESIS Expansion	MR RESCUE
患者例数/参与医院家数	656/58	362/24	127/22
研究起止年份	2006—2012	2008—2012	2004—2011
患者重要特征	AIS 3 h内；NIHSS≥10，或NIHSS 8～9但有CTA证实的动脉闭塞；在有急诊CTA的306例患者中，动脉闭塞占92%	AIS 4.5 h内；对NISHH没有要求；无动脉闭塞患者的百分率数据	AIS 8 h内；NIHSS6～29；所有患者均有前循环动脉闭塞证据；58%患者有半暗带
试验组介入诊治时间要求	无	无	无
试验组血管内治疗方法	动脉溶栓，Merci、Penumbra、Solitaire FR装置取栓	动脉溶栓，Merci、Penumbra、SolitaireFR、Trevo装置取栓	Merci、Penumbra装置取栓
试验组早期再通（TICI）	2a～3级：65%～81%；2b～3级：23%～44%	无可用数据	2a～3级：67%；2b～3级：无数据

Please choose a citation manager

Content to export

Inter ventional treatment for acute ischemia stroke：the latest international research result and national 973 research program of "MODIFIED" trial

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 1

References 8

Related Articles 0

Recommended Articles

Metrics

Comments

模态框（Modal）标题

Please choose a citation manager

Content to export

Inter ventional treatment for acute ischemia stroke：the latest international research result and national 973 research program of "MODIFIED" trial

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 1

References 8

Related Articles 0

Recommended Articles

Metrics

Comments