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中华介入放射学电子杂志 ›› 2026, Vol. 14 ›› Issue (01) : 103 -108. doi: 10.3877/cma.j.issn.2095-5782.2026.01.015

综述

线粒体自噬在脑缺血再灌注损伤中的机制及作用研究进展
陈海兰, 王黎洲()   
  1. 550004 贵阳,贵州医科大学医学影像学院
  • 收稿日期:2025-06-17 出版日期:2026-02-25
  • 通信作者: 王黎洲

Mitophagy in cerebral ischemia-reperfusion injury: mechanisms and therapeutic implications

Hailan Chen, Lizhou Wang()   

  1. School of Medical Imaging, Guizhou Medical University, Guiyang 550004, China
  • Received:2025-06-17 Published:2026-02-25
  • Corresponding author: Lizhou Wang
引用本文:

陈海兰, 王黎洲. 线粒体自噬在脑缺血再灌注损伤中的机制及作用研究进展[J/OL]. 中华介入放射学电子杂志, 2026, 14(01): 103-108.

Hailan Chen, Lizhou Wang. Mitophagy in cerebral ischemia-reperfusion injury: mechanisms and therapeutic implications[J/OL]. Chinese Journal of Interventional Radiology(Electronic Edition), 2026, 14(01): 103-108.

脑缺血再灌注损伤(cerebral ischemia-reperfusion injury, CIRI)是脑细胞缺血后血流恢复时,所引发功能障碍和细胞损伤的一种现象。脑缺血再灌注损伤过程中,线粒体自噬通过选择性自噬机制清除受损伤或功能失调线粒体,防止产生过多的活性氧从而防止细胞死亡。本文对线粒体自噬参与CIRI的信号通路、病理机制以及保护作用等进行了归纳、总结;同时,还探讨了线粒体自噬的双重作用机制及其精准调控的重要性,并指出当前该领域研究在临床转化中所面临的挑战,旨在为脑缺血的防治提供新的治疗策略。

Cerebral ischemia-reperfusion injury (CIRI) is a pathological phenomenon characterized by functional impairment and cellular damage that occurs following the restoration of blood flow after an ischemic event. During CIRI, mitophagy contributes to cellular homeostasis by selectively targeting and degrading damaged or dysfunctional mitochondria via autophagic mechanisms, thereby reducing excessive reactive oxygen species (ROS) generation and attenuating cell death. This review comprehensively summarizes the signaling pathways, pathological mechanisms, and neuroprotective roles of mitophagy in CIRI. Additionally, it examines the dual regulatory functions of mitophagy and highlights the critical importance of its precise modulation. The current challenges in clinical translation of these findings are also discussed, with the aim of facilitating the development of novel therapeutic strategies for the prevention and treatment of cerebral ischemia.

图1 线粒体自噬过程
图2 线粒体自噬调控机制
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