比较低功率（40 W）与高功率（100 W）微波消融对活体猪肺组织消融区域的变化情况。

对活体猪肺进行微波消融，根据消融功率分为40 W组和100 W组，设置消融时间各为1、3、5、8、10 min，每组实验重复3次，共30次消融。记录消融区域的最大长径、短径/厚度、体积及纵横比，取材观察消融区域的病理情况。

当消融功率一定时，随着时间的增加，消融区域的长径、短径/厚度、体积逐渐增大（均P<0.05）；40 W组消融时间在1~10 min时，其消融长径为（13.6±6.0） mm，短径/厚度为（10.4±3.8） mm，纵横比为1.3±0.2。100 W组消融时间在1~10 min时，其消融长径为（31.1±9.1） mm，短径/厚度为（19.9±6.5） mm，纵横比为1.6±0.2。40 W组在消融时间为8和10 min时，消融区域的长径、短径/厚度及体积的增加趋于平缓，长径和短径/厚度均未超过20 mm，且纵横比维持在1.3~1.4。而100 W组的消融区域长径和短径/厚度在相同时间内仍持续增长，纵横比维持在1.4~1.5。镜下可见消融区域从内到外依次为凝固性坏死区和肺组织充血水肿及炎性细胞浸润区，可见炎性细胞浸润。

消融时间相同的情况下，高功率（100 W）微波消融较低功率（40 W）微波消融能产生更大消融区域，更适用于直径大于20 mm病灶的消融治疗，其在临床中的应用值得进一步研究。

To compare the changes in the ablation zone of porcine lung tissue in vivo between low-power (40 W) and high-power (100 W) microwave ablation (MWA).

Microwave ablation was performed on porcine lungs in vivo. The ablation was divided into two groups based on power: 40 W and 100 W. Ablation times were set at 1 min, 3 min, 5 min, 8 min, and 10 min, with each group repeated three times, for a total of 30 ablations. The maximum long axis, short axis/thickness, volume, and aspect ratio of the ablation zone were recorded, and histological examination of the ablation zone was performed.

When the ablation power was constant, the long axis, short axis/thickness, and volume of the ablation zone increased gradually with time (all P<0.05). For the 40 W group with ablation times ranging from 1 to 10 minutes, the long axis of the ablation zone was 13.6±6.0 mm, the short axis/thickness was 10.4±3.8 mm, and the aspect ratio was 1.3±0.2. For the 100 W group with ablation times ranging from 1 to 10 minutes, the long axis of the ablation zone was 31.1±9.1 mm, the short axis/thickness was 19.9±6.5 mm, and the aspect ratio was 1.6±0.2. In the 40 W group, the increase in long axis, short axis/thickness, and volume of the ablation zone became stable at 8 min and 10 min of ablation, with neither long diameter nor short diameter/thickness exceeding 20 mm, and the aspect ratio remained between 1.3 and 1.4. In contrast, the long axis and short axis/thickness of the ablation zone in the 100 W group continued to increase within the same time frame, with the aspect ratio maintained between 1.4 and 1.5. Histologically, the ablation zone showed a coagulative necrosis zone at the center, surrounded by a zone of pulmonary tissue congestion, edema, and inflammatory cell infiltration, with visible inflammatory cell infiltration.

When the ablation time is the same, high-power (100 W) microwave ablation generates a larger ablation zone compared to low-power (40 W) microwave ablation and is more suitable for the ablation treatment of lesions with a diameter greater than 20 mm. Further investigation into its clinical application is warranted.