探索经后交通动脉进行眼动脉灌注化疗（intra-arterial chemotherapy via posterior communicating artery，p-IAC）在视网膜母细胞瘤（retinoblastoma，RB）中的可行性与安全性。

回顾性分析4例接受p-IAC的RB患儿资料。详细记录患儿性别、年龄、肿瘤分期、造影特点及不良反应等情况。

纳入的4例RB患儿中男性2例、女性2例，其中右眼3例（D期1例、E期2例）、左眼1例（E期），共行5次p-IAC。所有患儿眼动脉造影均见脉络膜显影良好，无栓塞灌注出现，亦无明显反流现象存在。灌注化疗药物过程中无导管脱落，术后除1例患儿出现眼睑肿胀外，其余3例患儿均未见明显不良反应。

p-IAC在RB的治疗中是可行的，对于因眼动脉角度问题导致插管困难的患儿可尝试p-IAC。

To investigate the feasibility and safety of Intra-arterial chemotherapy via posterior communicating artery (p-IAC) for retinoblastoma (RB).

We retrospectively analyzed 4 patients diagnosed with retinoblastoma undergoing p-IAC. We recorded the data including gender, age, tumor staging, arteries approached, arteriography features and adverse events of p-IAC.

A total of 4 RB patients (2 boys, 2 girls) were included in this study. 3 children had RB in the right eye ( 2 eyes were stage D and 1 eye was stage E according to the International Intraocular Retinoblastoma Classification) and1 child has RB in the left eye (stage E). There were 5 procedures in all cases with excellent choroid staining by ophthalmography, and no embolism perfusion or obvious reflux. No catheter shedding was observed during the infusion of chemotherapy drugs, and no obvious adverse reactions were observed in the other 3 cases except eyelid swelling in 1 case.

p-IAC is safe and feasible in the treatment of RB, and can be attempt to children with difficulty in intubation due to ocular artery angle problems.