分析不同年龄组及不同椎间盘突出类型的患者接受腰椎间盘三氧（Ozone，O₃）注射术后疗效的差别，为临床治疗的选择提供依据。

随访2009年1月到2019年6月在南方医院就诊的腰椎间盘突出症患者共476人（年龄在14~85岁之间，单一责任椎间盘）。根据MRI影像和DSA下O₃注射时的影像表现，我们将腰椎间盘突出症分为四型：Ⅰ型：纤维环破裂髓核突出型；Ⅱ型：纤维环破裂髓核非突出型；Ⅲ型：纤维环非破裂髓核突出型；Ⅳ型：纤维环非破裂髓核非突出型。VAS评分作为评价疗效的标准，我们记录了患者术前、术后1周、1、6和12个月的VAS评分并进行比较。

腰椎间盘O₃注射术对患者疼痛缓解有较好的疗效，有椎间盘突出的患者在治疗后可观察到突出减小。在年龄、性别、病程、突出类型等临床特征中，年龄是唯一与术后VAS相关因素，且呈负相关。不同年龄组患者疗效与分型相关，中青年组患者Ⅰ型疗效最好，Ⅳ型疗效最差；老年组患者Ⅱ型疗效最好，Ⅲ型最差。

腰椎间盘O₃注射术是一种有效的治疗腰椎间盘突出症的方法，但是不同年龄组间不同类型的患者疗效不同，在临床治疗中应根据患者特点选用不同治疗方案。

Analyze the difference in curative effect of patients of different age groups and different types of intervertebral disc herniation after receiving ozone (O₃) injection of lumbar intervertebral disc, and provide a basis for the choice of clinical treatment.

A total of 476 patients with lumbar disc herniation (aged between 14-85 years old, single responsibility disc) who were treated at Nanfang Hospital from January 2009 to June 2019 were followed up. According to the MRI images and the imaging manifestations during O₃ injection under DSA, we classified lumbar disc herniation into four types: Type Ⅰ: ruptured annulus fibrosus with herniated nucleus pulposus, TypeⅡ: ruptured annulus fibrosus withnon-protruding nucleus pulposus, Type Ⅲ : annulus fibrosus non-ruptured with herniated nucleus pulposus, and type Ⅳ: annulus fibrosus non-ruptured with non-protruding nucleus pulposus.The VAS score was used as a standard for evaluating the efficacy. We recorded the VAS scores of patients before surgery, 1 week, 1 month, 6 months and 12 months after surgery and compared them.

O₃ injection of lumbar intervertebral disc has a good effect on pain relief in patients. The reduction of herniation can be observed after treatment in patients with herniated intervertebral disc. Among clinical characteristics such as age, gender, course of disease, and prominent type, age was the only factor that was negatively correlatedwith postoperative VAS. The curative effect of patients in different age groups was related to the classification. The young and middle-aged patients have the best curative effect in type Ⅰ and the worst curative effect in type Ⅳ.The elderly group has the best curative effect in type Ⅱ and the worst effect in type Ⅲ.

Lumbar intervertebral disc O₃ injection is an effective method for the treatment of lumbar disc herniation, but different types of patients have different curative effects among different age groups. In clinical treatment, different treatment options should be selected based on the characteristics of patients.