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中华介入放射学电子杂志 ›› 2022, Vol. 10 ›› Issue (01) : 83 -87. doi: 10.3877/cma.j.issn.2095-5782.2022.01.015

综述

镍钛合金支架表面修饰进展
段林1, 何艳艳2, 李天晓2, 陈松2, 贺迎坤2,†(), 吴海刚3,†()   
  1. 1. 450003　河南郑州，河南大学人民医院卒中中心神经外科；河南省脑血管病国际联合实验室
    2. 河南省人民医院介入中心脑血管病科
    3. 475004　河南开封，河南大学生命科学院
  • 收稿日期:2021-04-07 出版日期:2022-02-25
  • 通信作者: 贺迎坤, 吴海刚
  • 基金资助:
    河南省高等学校重点科研项目(21A320002); 河南省中青年卫生健康科技创新人才培养项目(YXKC2020041); 河南省医学科技攻关计划省部共建青年项目(SBGJ202003004)

Progress in surface modification of nitinol stent

Lin Duan1, Yanyan He2, Tianxiao Li2, Song Chen2, Yingkun He2,†(), Haigang Wu3,†()   

  1. 1. Neurosurgery Department of Stroke Center, Henan University People's Hospital; Henan International Joint Laboratory of Cerebrovascular Disease
    2. Cerebrovascular Department of Interventional Center, Henan Provincial People's Hospital, Henan Zhengzhou 450003
    3. School of Sciences, Henan University, Henan Kaifeng 475004, China
  • Received:2021-04-07 Published:2022-02-25
  • Corresponding author: Yingkun He, Haigang Wu
  • About author:
    Co-first authors: Duan Lin, He Yanyan
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段林, 何艳艳, 李天晓, 陈松, 贺迎坤, 吴海刚. 镍钛合金支架表面修饰进展[J]. 中华介入放射学电子杂志, 2022, 10(01): 83-87.

Lin Duan, Yanyan He, Tianxiao Li, Song Chen, Yingkun He, Haigang Wu. Progress in surface modification of nitinol stent[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(01): 83-87.

近年来生物金属材料已被广泛应用于医疗领域，大多数原材料为钴铬、铁、镁、锌、镍、钛等；其中镍钛合金（NiTi）因具有优异的机械性能和良好的生物相容性，外加微创介入医学的兴起及其在治疗方面对医疗耗材器械精准化的需求，使NiTi在血管介入治疗中被广泛应用。但NiTi支架在生物相容性、耐腐蚀性、术后内皮化延迟及再狭窄等方面的问题仍有待解决。通过对NiTi材料进行精细的设计和适宜的表面涂层修饰，提高医用NiTi的生物相容性和耐腐蚀性，是NiTi未来研究发展的重要方向。文章将从NiTi的生物学特性、表面修饰两个方面，阐述NiTi作为支架材料的研究现状，并系统分析其在血管植入物方面面临的问题。

关键词: 镍钛合金, 涂层, 生物医用材料

Recently, the biological metal materials have been widely utilized in medicinal implantation, and the main component of these materials are cobalt chromium, iron, magnesium, zinc, nickel and titanium, respectively. Owing to the excellent of mechanical properties and biocompatibility of nitinal, NiTi alloys have been widely applied in vascular interventional treatment. However, the critical unsolved problems of NiTi alloy network contains the immune-response, anti-erosion, delayed endothelialization and restenosis, which have limited the further application in vascular interventional treatments. By precisely regulating the components of coating layers of NiTi alloys, the biocompatibility and anti-erosion can be significantly improved, which is the critical direction for medical alloy surface modification. In this paper, the current research status of NiTi alloys as scaffold material is described from the biological characteristics and surface modification of NiTi alloys, and the problems faced by it in vascular implants are systematically analyzed.

Key words: Nitinol, Coating, Biomedical materials
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