微小RNA在脑缺血再灌注损伤中的研究现状与进展

doi:10.3877/cma.j.issn.2095-5782.2022.01.014

脑缺血性卒中是导致成人死亡和残疾的主要原因之一，血管再通获得及时的再灌注是临床治疗的首选方法，然而再灌注可诱发脑缺血再灌注损伤。研究结果显示，微小RNA（miRs）可作为潜在的治疗靶点，在脑缺血再灌注损伤中发挥重要作用。作为近年研究的热点，miRs的异常表达及功能受到更多关注。尽管已有相关研究提示了调节miRs对治疗脑缺血再灌注损伤的安全性和有效性，然而，目前尚缺乏相关的随机对照临床研究数据来证实，以确定统一标准指导。文章就miRs参与脑缺血再灌注损伤的信号通路、病理机制、以及各种相互作用等进行综述。

关键词: 脑缺血再灌注损伤, 微小RNA, 治疗靶点

Ischemic stroke is one of the leading cause of death and disability in adults. Vascular recanalization to obtain timely reperfusion is the preferred treatment in clinical practice. However, reperfusion can induce cerebral ischemia-reperfusion injury (CIRI). The present research reveal that microRNAs (miRs) have been implicated in CIRI and could serve as therapeutic targets. As a research hotspot, the abnormal expression and function of miRs have been receiving more and more attention. Although relevant studies have suggested the safety and effectiveness of regulating miRs in the treatment of CIRI, there are no randomized controlled trials to formulate uniform standard guideline. This article aims to make a comprehensive review about the current status and progress of the research on the signaling pathways, pathological mechanisms, and various interactions of miRs involved in CIRI.

Key words: Cerebral ischemia-reperfusion injury, MicroRNAs, Therapeutic targets

表1 miRNA在CIRI中的表达

进程	CIRI诱导下调	靶点	参考文献	CIRI诱导上调	靶点	参考文献
凋亡相关
	miR-211	PUMA	[54]	miR-99b	IGF1R	[54]
	miR-874-3p	BCL2LI3	[54]	miR-106-5p	Mcl-1	[54]
	miR-29a	AQP4	[54]	miR-138	SIRT1	[54]
	miR-496	BCL2LI4	[54]	miR-224-3p	FIP200	[54]
	miR-544	IRAK4	[54]	miR-155	GATA3	[54]
	miR-219a-5p	Pde4d	[54]	miR-429	GTAA3	[54]
	miR-26a-5p	DAPK1	[54]	miR-10a	PI3K	[54]
	miR-137	Notch1	[54]	miR-223	IGF1R	[54]
	miR-124	Ku70	[54]	miR-370	SIRT1	[54]
	miR-431	Rho	[54]	miR-128	WNT1	[32]
与氧化应激相关
	miR-144-3p	Brg1	[54]	miR-144	Nrl2	[54]
	miR-652	NOX2	[54]	miR-142-5p	Nrl2	[54]
	miR-124-5p	NOX2	[54]	miR-153	Nrl2	[54]
	miR-7a-5p	a-Syn	[54]	miR-93	Nrl2	[54]
	miR-375	Ctgf	[54]	miR-217	SIRT1	[54]
	miR-29a	PUMA	[54]	miR-135a	GSK-3β	[54]
	miR-455-3p	TP53INP1	[54]	miR-224-3p	FIP200	[54]
				miR-421	MCL1	[54]
				miR-134	Nrf2	[39]
与炎症反应相关
	miR-223	NLRP3	[54]	miR-193b-3p	5-LOX	[54]
	miR-211-5p	COX-2	[54]	miR-19a-3p	IGFBP3	[54]
	miR-338-5p	Ctgf	[54]	miR-155	MafB	[54] [30]
	miR-544	IRAK4	[54]	miR-217	SIRT1	[13][54]
	miR-182-5p	TLR4	[54]	miR-124	RhoA	[28][29]
	miR-146a	IRAK1	[54]
	miR-338-5p	Ctgf	[26]
	miR-1906	JAK2/STAT3	[22]
	miR-22	VEGF	[27]
与兴奋性毒性相关
	miR-1000	VGlut	[54]	miR-107	GLT-1	[54]
	miR-223	GluR2，NR2B	[54]
与细胞自噬相关
	miR-30	Beclin1	[54]	miR-124	PI3K	[54]
	miR-298	Act1	[54]
	miR-138	SIRT1	[54]
	miR-202-5p	eIF4E	[54]
与血脑屏障功能相关
	miR-539	MMP-9	[54]	miR-130a	—	[52]
	miR-21	MAP2K	[52] [54]	miR-150	—	[52]

	miR-429	Cxcll	[54]	miR-17	—	[52]
	miR-149-5p	SIPR2	[54]	miR-222	—	[52]
	miR-126	—	[52]	miR-378	—	[52]
	miR-150	—	[52]	miR-20a	—	[52]
				miR-19a/b	—	[52]
低氧（HIF-1）
	miR-613	ATG3轴	[21]	miR-373	—	[52]
	miR-26b	—	[29]	miR-24-1	—	[52]
				miR-181c	—	[52]
				miR-210	—	[52]
				miR-26a-2	—	[52]
				miR-23	—	[52]
				miR-24	—	[52]
				miR-103	—	[52]
				miR-107	—	[52]
其他
	miR-148b-3	—	[57]	miR-292-5p	—	[52]
	miR-488-3p	—	[53]	miR-290	—	[52]
				miR-206	—	[52]
				miR-215	—	[52]
				miR-214	—	[52]
				miR-223	—	[52]
				miR-298	—	[52]
				miR-327	—	[52]
				miR-494	Sox8	[52]
				miR-497	—	[52]
				miR-7674-5p	—	[57]

表1 miRNA在CIRI中的表达

进程	CIRI诱导下调	靶点	参考文献	CIRI诱导上调	靶点	参考文献
凋亡相关
	miR-211	PUMA	[54]	miR-99b	IGF1R	[54]
	miR-874-3p	BCL2LI3	[54]	miR-106-5p	Mcl-1	[54]
	miR-29a	AQP4	[54]	miR-138	SIRT1	[54]
	miR-496	BCL2LI4	[54]	miR-224-3p	FIP200	[54]
	miR-544	IRAK4	[54]	miR-155	GATA3	[54]
	miR-219a-5p	Pde4d	[54]	miR-429	GTAA3	[54]
	miR-26a-5p	DAPK1	[54]	miR-10a	PI3K	[54]
	miR-137	Notch1	[54]	miR-223	IGF1R	[54]
	miR-124	Ku70	[54]	miR-370	SIRT1	[54]
	miR-431	Rho	[54]	miR-128	WNT1	[32]
与氧化应激相关
	miR-144-3p	Brg1	[54]	miR-144	Nrl2	[54]
	miR-652	NOX2	[54]	miR-142-5p	Nrl2	[54]
	miR-124-5p	NOX2	[54]	miR-153	Nrl2	[54]
	miR-7a-5p	a-Syn	[54]	miR-93	Nrl2	[54]
	miR-375	Ctgf	[54]	miR-217	SIRT1	[54]
	miR-29a	PUMA	[54]	miR-135a	GSK-3β	[54]
	miR-455-3p	TP53INP1	[54]	miR-224-3p	FIP200	[54]
				miR-421	MCL1	[54]
				miR-134	Nrf2	[39]
与炎症反应相关
	miR-223	NLRP3	[54]	miR-193b-3p	5-LOX	[54]
	miR-211-5p	COX-2	[54]	miR-19a-3p	IGFBP3	[54]
	miR-338-5p	Ctgf	[54]	miR-155	MafB	[54] [30]
	miR-544	IRAK4	[54]	miR-217	SIRT1	[13][54]
	miR-182-5p	TLR4	[54]	miR-124	RhoA	[28][29]
	miR-146a	IRAK1	[54]
	miR-338-5p	Ctgf	[26]
	miR-1906	JAK2/STAT3	[22]
	miR-22	VEGF	[27]
与兴奋性毒性相关
	miR-1000	VGlut	[54]	miR-107	GLT-1	[54]
	miR-223	GluR2，NR2B	[54]
与细胞自噬相关
	miR-30	Beclin1	[54]	miR-124	PI3K	[54]
	miR-298	Act1	[54]
	miR-138	SIRT1	[54]
	miR-202-5p	eIF4E	[54]
与血脑屏障功能相关
	miR-539	MMP-9	[54]	miR-130a	—	[52]
	miR-21	MAP2K	[52] [54]	miR-150	—	[52]

	miR-429	Cxcll	[54]	miR-17	—	[52]
	miR-149-5p	SIPR2	[54]	miR-222	—	[52]
	miR-126	—	[52]	miR-378	—	[52]
	miR-150	—	[52]	miR-20a	—	[52]
				miR-19a/b	—	[52]
低氧（HIF-1）
	miR-613	ATG3轴	[21]	miR-373	—	[52]
	miR-26b	—	[29]	miR-24-1	—	[52]
				miR-181c	—	[52]
				miR-210	—	[52]
				miR-26a-2	—	[52]
				miR-23	—	[52]
				miR-24	—	[52]
				miR-103	—	[52]
				miR-107	—	[52]
其他
	miR-148b-3	—	[57]	miR-292-5p	—	[52]
	miR-488-3p	—	[53]	miR-290	—	[52]
				miR-206	—	[52]
				miR-215	—	[52]
				miR-214	—	[52]
				miR-223	—	[52]
				miR-298	—	[52]
				miR-327	—	[52]
				miR-494	Sox8	[52]
				miR-497	—	[52]
				miR-7674-5p	—	[57]

表2 在CIRI中miRs的影响

促CIRI发生发展	信号通路/轴	参考文献	改善CIRI预后	信号通路/轴	参考文献
miR-217	NF-κB	[13]	miR-579-3p	NF-κB	[14]
miR-22	PI3K/AKT/mTOR JAK/STAT3	[27]	miR-193b-3p	NF-κB	[15]
miR-10a	PI3K/Akt/mTOR	[19]	miR-429	NF-κB	[16]
miR-455-3p	TP53INP1轴	[34]	miR-26b-5p	NF-κB	[17]
miR-134	CREB/Nrf2	[39]	miR-1906	NF-κB	[18]
miR-148b-3p	Sestrin2/Nrf2/ARE轴	[40]	miR-182-5p	NF-κB	[18]
miR-302b3p	GSK-3β)/Nrf2/ARE轴	[41]	miR-372-3p	NF-κB	[18]
miR-199a-5p	Brg1)/Nrf2/HO-1轴	[42]	miR-26	PTEN轴	[19]
miR-10a	caspase-3活性和Bax	[19]	miRNA-26b-5p	PTEN轴	[20]
miR-224-3p	caspase-3	[54]	miR-216a	JAK2/STAT3	[22]
miR-155	caspase-3	[54]	miR-1906	JAK2/STAT3	[22]
miR-429	caspase-3	[54]	miR-26a	PI3K/Akt、MAPK/ERK	[19]
miR-10a	PI3K/Akt/ mTOR	[54]	miR-338-5p	AMPK/mTOR	[26]
miR-370	SIRT6	[54]	miR-375	p21/PI3K/Akt	[19]
miR-144	Nrf2/ARE轴	[54]	miR-124	PI3K/Akt/ mTOR	[29]
miR-142-5p	Nrf2/ARE轴	[54]	miR-128-3p	MAPK WNT1	[32][33]
miR-153	Nrf2/ARE轴	[54]	miR-30b	PI3K/Akt/eNOS	[44]
miR-93	Nrf2/ARE轴	[54]	miR-424	PI3K/Akt/eNOS	[44]
miR-217	SIRT1	[54]	miR-126	PI3K/Akt/eNOS	[29]
miR-135a	GSK-3β	[54]	miR-451a	靶向Rac1	[45]
miR-421	MCL1	[54]	miR-193b-3p	5-脂氧合酶	[15]
miR-224-3p	FIP200	[54]	miR-204-5p	NF-κB	[46]
miR-193b-3p	5-LOX	[54]	miR-579-3p	炎性细胞因子TNF-a	[14]
miR-19a-3p	IGFBP3	[54]	miR-193b-3p	抑制TGF-β活性	[15]
miR-155	MafB	[54]	miR-22-3p	caspase-3活性和Bax	[49]
				BMF/BMP2轴
miR-217	SIRT1	[54]	miR-579-3p	caspase-3活性和Bax	[14]
miR-107	GLT-1	[54]	miR-26a	caspase-3活性和Bax	[19]
miR-124	PI3K/Akt/eNOS	[54]	miR-488-3p	靶向VPS4B	[53]

表2 在CIRI中miRs的影响

促CIRI发生发展	信号通路/轴	参考文献	改善CIRI预后	信号通路/轴	参考文献
miR-217	NF-κB	[13]	miR-579-3p	NF-κB	[14]
miR-22	PI3K/AKT/mTOR JAK/STAT3	[27]	miR-193b-3p	NF-κB	[15]
miR-10a	PI3K/Akt/mTOR	[19]	miR-429	NF-κB	[16]
miR-455-3p	TP53INP1轴	[34]	miR-26b-5p	NF-κB	[17]
miR-134	CREB/Nrf2	[39]	miR-1906	NF-κB	[18]
miR-148b-3p	Sestrin2/Nrf2/ARE轴	[40]	miR-182-5p	NF-κB	[18]
miR-302b3p	GSK-3β)/Nrf2/ARE轴	[41]	miR-372-3p	NF-κB	[18]
miR-199a-5p	Brg1)/Nrf2/HO-1轴	[42]	miR-26	PTEN轴	[19]
miR-10a	caspase-3活性和Bax	[19]	miRNA-26b-5p	PTEN轴	[20]
miR-224-3p	caspase-3	[54]	miR-216a	JAK2/STAT3	[22]
miR-155	caspase-3	[54]	miR-1906	JAK2/STAT3	[22]
miR-429	caspase-3	[54]	miR-26a	PI3K/Akt、MAPK/ERK	[19]
miR-10a	PI3K/Akt/ mTOR	[54]	miR-338-5p	AMPK/mTOR	[26]
miR-370	SIRT6	[54]	miR-375	p21/PI3K/Akt	[19]
miR-144	Nrf2/ARE轴	[54]	miR-124	PI3K/Akt/ mTOR	[29]
miR-142-5p	Nrf2/ARE轴	[54]	miR-128-3p	MAPK WNT1	[32][33]
miR-153	Nrf2/ARE轴	[54]	miR-30b	PI3K/Akt/eNOS	[44]
miR-93	Nrf2/ARE轴	[54]	miR-424	PI3K/Akt/eNOS	[44]
miR-217	SIRT1	[54]	miR-126	PI3K/Akt/eNOS	[29]
miR-135a	GSK-3β	[54]	miR-451a	靶向Rac1	[45]
miR-421	MCL1	[54]	miR-193b-3p	5-脂氧合酶	[15]
miR-224-3p	FIP200	[54]	miR-204-5p	NF-κB	[46]
miR-193b-3p	5-LOX	[54]	miR-579-3p	炎性细胞因子TNF-a	[14]
miR-19a-3p	IGFBP3	[54]	miR-193b-3p	抑制TGF-β活性	[15]
miR-155	MafB	[54]	miR-22-3p	caspase-3活性和Bax	[49]
				BMF/BMP2轴
miR-217	SIRT1	[54]	miR-579-3p	caspase-3活性和Bax	[14]
miR-107	GLT-1	[54]	miR-26a	caspase-3活性和Bax	[19]
miR-124	PI3K/Akt/eNOS	[54]	miR-488-3p	靶向VPS4B	[53]

[1]	胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220.
[2]	张艾嘉, 王爽, 王萍, 等.缺血性脑卒中的病理机制研究进展及中医药防治[J]. 中国实验方剂学杂志, 2020, 26(5): 227-240.
[3]	Wu G, Zhu L, Yuan X, et al. Britanin ameliorates cerebral ischemia-reperfusion injury by inducing the Nrf2 protective pathway[J]. Antioxidants and Redox Signalling, 2017, 27(11):754-768.
[4]	Ye J, Das S, Roy A, et al. Ischemic injury-induced CaMKIIδ and CaMKIIγ confer neuroprotection through the NF-κB signaling pathway[J]. Molecular Neurobiology, 2019, 56(3): 2123-2136.
[5]	彭智远, 刘旺华, 曹雯. 脑缺血再灌注损伤细胞凋亡机制的研究进展[J]. 中华中医药学刊, 2017, 35(8): 1957-1961.
[6]	Gao JQ, Wang P, Yan JW, et al. Shear stress rescued the neuronal impairment induced by global cerebral ischemia reperfusion via activating PECAM-1-eNOS-NO pathway[J]. Front Cell Dev Biol, 2020, 8: 631286-631286.
[7]	Liu G, Wang T, Wang T, et al. Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats[J]. Biomed Rep.2013, 1(6): 861-867.
[8]	陈萌, 梁秀军, 王爱乐, 等. 脑缺血再灌注损伤大鼠Beclin-1与Bcl-xL、Caspase-2的表达及Cystatin C干预作用的影响[J]. 中风与神经疾病杂志, 2017, 34(9): 801-806.
[9]	Gowen A, Shahjin F, Chand S, et al. Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications[J]. Front Cell Dev Biol, 2020, 8: 149-149.
[10]	Robbins PD, Dorronsoro A, Booker CN. Regulation of chronic inflammatory and immune processes by extracellular vesicles[J].J Clin Invest, 2016, 126(4): 1173-1180.
[11]	杨鹏, 何洋, 李成, 等. 微小核糖核酸-7调控表皮细胞生长因子受体对肝癌细胞增殖和转移的影响[J]. 介入放射学杂志, 2021, 30(1): 43-47.
[12]	Zhang X, Liu L, Yuan X, et al. JMJD3 in the regulation of human diseases[J]. Protein Cell, 2019, 10(12): 864-882.
[13]	Rao G, Zhang W, Song S. MicroRNA217 inhibition relieves cerebral ischemia/reperfusion injury by targeting SIRT1[J]. Mol Med Rep, 2019, 20(2): 1221-1229.
[14]	Jia J, Cui Y, Tan Z, et al. MicroRNA-579-3p exerts neuroprotective effects against ischemic stroke via anti-inflammation and anti-apoptosis[J]. Neuropsychiatr Dis Treat, 2020, 16: 1229-1238.
[15]	Chen Z, Yang J, Zhong J, et al. MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression[J]. Exp Neurol 2020, 327: 113223.
[16]	Leng J, Liu W, Li L, et al. MicroRNA-429/cxcl1 axis protective against oxygen glucose deprivation/reoxygenation-induced injury in brain microvascular endothelial cells[J]. Dose Response, 2020, 18(2): 1559325820913785.
[17]	Li G, Xiao L, Qin H, et al. Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion[J]. Cell Cycle, 2020, 19(9): 1022-1035.
[18]	Yang B, Zang L, Cui J, et al. Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction[J]. Stem Cell Res Ther, 2021, 12(1): 125.
[19]	Guo XL, Liang H, Sun Y, et al. MicroRNA-26a regulates cerebral ischemia injury through targeting PTEN[J]. Eur Rev Med Pharmacol Sci, 2019, 23(16): 7033-7041.
[20]	Xiao Y, Zheng S, Duan N, et al. MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression[J]. Hum Exp Toxicol, 2021, 40(8): 1250-1262.
[21]	Wei L, Peng Y, Yang XJ, et al. Knockdown of long non-coding RNA RMRP protects cerebral ischemia-reperfusion injury via the microRNA-613/ATG3 axis and the JAK2/STAT3 pathway[J]. Kaohsiung J Med Sci, 2021, 37(6): 468-478.
[22]	Yu X, Li X. microRNA-1906 protects cerebral ischemic injury through activating Janus kinase 2/signal transducer and activator of transcription 3 pathway in rats[J]. Neuroreport, 2020, 31(12): 871-878.
[23]	Sabatini DM. mTOR and cancer: insights into a complex relationship[J]. Nat Rev Cancer, 2006, 6(9): 729-34.
[24]	Averous J, Proud CG. When translation meets transformation: the mTOR story[J]. Oncogene, 2006, 25(48): 6423-6435.
[25]	向雷, 黄智, 张帅, 等.磷脂酰肌醇3激酶调节亚基1过表达对肝细胞癌进展的影响[J]. 介入放射学杂志, 2019, 28(10): 962-968.
[26]	Yi X, Fang Q, Li L. MicroRNA-338-5p alleviates cerebral ischemia/reperfusion injury by targeting connective tissue growth factor through the adenosine 5'-monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathway[J]. Neuroreport, 2020, 31(3): 256-264.
[27]	Sun H, Shi K, Xie D, et al. Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22[J].J Cell Physiol, 2019, 234(11): 20623-20633.
[28]	Miao W, Yan Y, Bao TH, et al. Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124[J]. Biomed Pharmacother, 2020, 126: 109786.
[29]	Hao R, Sun B, Yang L, et al. RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery[J]. Drug Deliv, 2020, 27(1): 772-781.
[30]	Jiang T, Zhou S, Li X, et al. MicroRNA-155 induces protection against cerebral ischemia/reperfusion injury through regulation of the Notch pathway in vivo[J]. Exp Ther Med, 2019, 18(1): 605-613.
[31]	Daskalopoulos EP, Blankesteijn WM. Effect of interventions in WNT signaling on healing of cardiac injury: a systematic review[J]. Cells, 2021, 10(2): 207.
[32]	Fang H, Li HF, Yang M, et al. MicroRNA-128 enhances neuroprotective effects of dexmedetomidine on neonatal mice with hypoxic-ischemic brain damage by targeting WNT1[J]. Biomed Pharmacother, 2019, 113: 108671.
[33]	Liu P, Han Z, Ma Q, et al. Upregulation of microRNA-128 in the peripheral blood of acute ischemic stroke patients is correlated with stroke severity partially through inhibition of neuronal cell cycle reentry[J]. Cell Transplant, 2019, 28(7): 839-850.
[34]	Fan Y, Wei L, Zhang S, et al. LncRNA SNHG15 knockdown protects against OGD/R-induced neuron injury by downregulating TP53INP1 expression via binding to miR-455-3p[J]. Neurochem Res, 2021, 46(4): 1019-1030.
[35]	Wang J, Toan S, Zhou H. New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury[J]. Angiogenesis, 2020, 23(3): 299-314.
[36]	Zhou M, Yu T, Fang X, et al. Short-term dietary restriction ameliorates brain injury after cardiac arrest by modulation of mitochondrial biogenesis and energy metabolism in rats[J]. Ann Transl Med, 2021, 9(1): 8.
[37]	Achzet LM, Davison CJ, Shea M, et al. Oxidative stress underlies the ischemia/reperfusion-induced internalization and degradation of AMPA receptors[J]. Int J Mol Sci, 2021, 22(2): 717.
[38]	Wang C, Wan H, Wang Q, et al. Safflor yellow B attenuates ischemic brain injury via downregulation of long noncoding AK046177 and inhibition of microRNA-134 expression in rats[J]. Oxid Med Cell Longev, 2020, 2020: 4586839.
[39]	Du Y, Ma X, Ma L, et al. Inhibition of microRNA-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling[J]. Clin Exp Pharmacol Physiol, 2020, 47(4): 561-570.
[40]	Zhang Z, Wang N, Zhang Y, et al. Downregulation of microRNA-302b-3p relieves oxygen-glucose deprivation/re-oxygenation induced injury in murine hippocampal neurons through up-regulating Nrf2 signaling by targeting fibroblast growth factor 15/19[J]. Chem Biol Interact, 2019, 309: 108705.
[41]	Li F, Liang J, Tong H, et al. Inhibition of microRNA-199a-5p ameliorates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO-1 signalling[J]. Clin Exp Pharmacol Physiol, 2020, 47(6): 1020-1029.
[42]	Zou ZY, Liu J, Chang C, et al. Biliverdin administration regulates the microRNA-mRNA expressional network associated with neuroprotection in cerebral ischemia reperfusion injury in rats[J]. Int J Mol Med, 2019, 43(3): 1356-1372.
[43]	Li H, Luo Y, Liu P, et al. Exosomes containing miR-451a is involved in the protective effect of cerebral ischemic preconditioning against cerebral ischemia and reperfusion injury[J]. CNS Neurosci Ther, 2021, 27(5): 564-576.
[44]	Pan Q, Wang Y, Lan Q, et al. Exosomes derived from mesenchymal stem cells ameliorate hypoxia/reoxygenation-injured ECs via transferring microRNA-126[J]. Stem Cells Int, 2019, 2019: 2831756.
[45]	Zhang H, Park JH, Maharjan S, et al. Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood-brain barrier disruption and inflammation[J].J Neuroinflammation, 2017, 14(1): 122.
[46]	Diaz-Cañestro C, Reiner MF, Bonetti NR, et al. AP-1 (activated protein-1) transcription factor JunD regulates ischemia/reperfusion brain damage via IL-1β (interleukin-1β)[J]. Stroke, 2019, 50(2): 469-477.
[47]	Jiang S, Dandu C, Geng X. Clinical application of nitric oxide in ischemia and reperfusion injury: a literature review[J]. Brain Circ, 2020, 6(4): 248-253.
[48]	Liu G, Wang T, Wang T, et al. Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats[J]. Biomed Rep, 2013, 1(6): 861-867.
[49]	Zhang Y, Liu J, Su M, et al. Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis[J]. Stem Cell Res Ther, 2021, 12(1): 111.
[50]	Zhu Y, Yu J, Gong J, et al. PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia[J]. Aging (Albany NY), 2021, 13(3): 3405-3427.
[51]	Fu K, Chen M, Zheng H, et al. Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway[J]. Transl Neurosci, 2021, 12(1): 20-31.
[52]	Yin KJ, Hamblin M, Chen YE. Angiogenesis-regulating microRNAs and ischemic stroke[J]. Curr Vasc Pharmacol, 2015, 13(3): 352-365.
[53]	Zhou L, Yang W, Yao E, et al. MicroRNA-488-3p regulates neuronal cell death in cerebral ischemic stroke through vacuolar protein sorting 4B (VPS4B)[J]. Neuropsychiatr Dis Treat, 2021, 17: 41-55.
[54]	李俊杰, 蒋海燕, 彭丽佳, 等.微小RNAs-mRNAs调控轴在脑缺血-再灌注损伤机制中的作用进展[J/OL]. 重庆医科大学学报: 1-8[2021-02-17]. https://doi.org/10.13406/j.cnki.cyxb.002658.
[55]	Kong Y, Han JH. MicroRNA: biological and computational perspective[J]. Genomics Proteomics & Bioinformatics, 2005, 3(2): 62-72.
[56]	Jeyaseelan K, Herath WB, Armugam A. MicroRNAs as therapeutic targets in human diseases[J]. Expert Opin Ther Targets, 2007, 11(8): 1119-29.
[57]	Takata T, Nonaka W, Iwama H, et al. Light exercise without lactate elevation induces ischemic tolerance through the modulation of microRNA in the gerbil hippocampus[J]. Brain Res, 2020, 1732: 146710.

[1]	张中斌, 付琨朋, 朱凯, 张玉, 李华. 胫骨高位截骨术与富血小板血浆治疗膝骨关节炎的疗效[J/OL]. 中华关节外科杂志(电子版), 2023, 17(05): 633-641.
[2]	费扬, 赵晗希, 孙丽琴, 楼琴华, 胡骏程. 银杏叶提取物对糖尿病肾病患者的疗效及其对尿液外泌体miR-342-3p的干预研究[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(03): 219-224.
[3]	卢凯, 王香云. 急性心肌梗死后心力衰竭患者血清微小RNA-200a表达及临床意义[J/OL]. 中华危重症医学杂志(电子版), 2023, 16(06): 488-491.
[4]	白香妮, 孙巨军, 谢鹤, 李宏斌. 急性胰腺炎患者血清微小RNA-142-3p和磷脂酰肌醇3-激酶水平变化及对并发腹腔感染风险预测[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 222-228.
[5]	乌吉斯古楞, 哈斯高娃. mir-98-5p、ALKBH1在肝门部胆管癌组织中表达及与临床病理特征的关系[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 184-187.
[6]	李智, 冯芸. NF-κB 与MAPK 信号通路及其潜在治疗靶点在急性呼吸窘迫综合征中的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 840-843.
[7]	郝春艳, 吉泽, 成苏杭, 李文思, 王丹. 血清miR-155联合sCD14水平判断慢性阻塞性肺疾病预后的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(01): 87-90.
[8]	孙璐, 蒋亚玲, 陈凌君. 布托啡诺对脑缺血再灌注损伤大鼠神经炎症和JAK2/STAT3信号通路的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 344-350.
[9]	陈惠燕, 吴瑶, 黄宗炫, 卜歆, 王庆惠, 纪辉涛, 陈银珍, 赵虎. 肾间质纤维化中胶原/DDR2 信号活化对肾成纤维细胞增殖和迁移功能影响的实验研究[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 294-302.
[10]	李京, 牛博, 刘晓蓓, 魏新雪, 黄荣. circ-SESN2 沉默靶向调控miRNA-23a-5p/ULK1 在神经细胞氧化应激损伤中的作用机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 263-272.
[11]	张艺, 任秀君, 郭孟玮, 赵雅芳, 李一凡, 李佳阳, 任晓暄, 邬继红, 卢海洋. 电针预处理对脑缺血再灌注大鼠行为学及外周血内皮祖细胞的影响[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(02): 71-77.
[12]	王燕, 梁海乾, 郭姗姗. 炎症小体在创伤性脑损伤中作用的研究进展[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(03): 177-181.
[13]	王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[14]	袁媛, 赵良平, 刘智慧, 张丽萍, 谭丽梅, 閤梦琴. 子宫内膜癌组织中miR-25-3p、PTEN的表达及与病理参数的关系[J/OL]. 中华临床医师杂志(电子版), 2023, 17(09): 1016-1020.
[15]	刘俊彬, 张晓婷, 郭镜培, 刘佳妮, 于本帅, 张可, 周斌. 熊果酸通过抑制NLRP3介导的小胶质细胞焦亡减轻脑缺血再灌注损伤的研究[J/OL]. 中华介入放射学电子杂志, 2024, 12(03): 221-227.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Research status and progress of microRNA in cerebral ischemia-reperfusion injury

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Research status and progress of microRNA in cerebral ischemia-reperfusion injury