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中华介入放射学电子杂志 ›› 2019, Vol. 07 ›› Issue (03) : 243 -250. doi: 10.3877/cma.j.issn.2095-5782.2019.03.015

所属专题: 文献

综述

肝癌分子靶向药物及免疫抑制剂治疗的研究现状及进展
周晨1, 刘家成1, 石钦1, 郑传胜1, 熊斌1,()   
  1. 1. 430022 武汉,华中科技大学同济医学院附属协和医院放射科、湖北省分子影像重点实验室
  • 收稿日期:2019-03-20 出版日期:2019-08-01
  • 通信作者: 熊斌
  • 基金资助:
    国家自然科学基金资助项目(81873917)

Current situation and research advances of molecular targeted drugs and immunosuppressive therapy for hepatocellular carcinoma

Chen Zhou1, Jiacheng Liu1, Qin Shi1, Chuansheng Zheng1, Bin Xiong1,()   

  1. 1. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
  • Received:2019-03-20 Published:2019-08-01
  • Corresponding author: Bin Xiong
  • About author:
    Corresponding author: Xiong Bin, Email:
引用本文:

周晨, 刘家成, 石钦, 郑传胜, 熊斌. 肝癌分子靶向药物及免疫抑制剂治疗的研究现状及进展[J]. 中华介入放射学电子杂志, 2019, 07(03): 243-250.

Chen Zhou, Jiacheng Liu, Qin Shi, Chuansheng Zheng, Bin Xiong. Current situation and research advances of molecular targeted drugs and immunosuppressive therapy for hepatocellular carcinoma[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2019, 07(03): 243-250.

肝癌是全球癌症发病率第6位,死亡率第3位的恶性肿瘤。肝癌发病隐匿且发展迅速,多数患者发现时病情就已经进展到中晚期,丧失了手术根治的机会。索拉非尼作为抗血管生成的分子靶向药物开启了肝癌分子靶向治疗的先河,在随后的近十年内,针对肝癌的靶向药物不断涌现,瑞戈非尼、乐伐替尼、卡博替尼、雷莫芦单抗以及一些免疫抑制剂在Ⅲ期临床试验方面取得了不错的成绩。本文就新出现的抗血管分子靶向药物及免疫抑制剂治疗肝癌的现状、挑战以及未来的发展方向进行综述。

Hepatic carcinoma (HCC) is the sixth most common malignant tumor in the world and the third leading cause of death. Due to the hidden nature of onset of HCC, most patients are already at the intermediate or advanced stage at the time of diagnosis and are not candidates for curative surgical treatment. Sorafenib, as a molecular targeted drug against angiogenesis, has opened the door of molecular targeted therapy for HCC since 2007, systemic treatment has become one of the hotspots in the treatment of HCC. In the following decade, targeted drugs for HCC developed, such as regorafenib, levovirinib, cabozantinib, remollozumab and some immune checkpoint inhibitors, and they have achieved good results in phase III clinical trials. This review describes the current status of anti-vascular molecular targeted therapy and immunosuppressive agents in the treatment of HCC, the challenges to be solved and the possible future development.

表1 晚期肝癌的三期临床试验
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