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中华介入放射学电子杂志 ›› 2013, Vol. 01 ›› Issue (02) : 32 -35. doi: 10.3877/cma.j.issn.2095-5782.2013.02.009

肿瘤介入

C形臂碘油CT在肝癌肝动脉化疗栓塞术中的应用价值
李建军1, 郑加生1,(), 崔雄伟1, 孙斌1, 房达1, 叶琳超2   
  1. 1.100069 首都医科大学附属北京佑安医院肿瘤微创介入中心
    2.西门子(中国)有限公司X线及血管造影事业部
  • 收稿日期:2013-05-04 出版日期:2013-11-01
  • 通信作者: 郑加生
  • 基金资助:
    国家“十二五”科技支撑计划项目课题(2012BAI15B08)

Application value of C-arm lipiodol CT in transhepatic arterial chemoembolization for hepatocellular carcinoma

Jianjun Li1, Jiasheng Zheng1,(), Xiongwei Cui1, Bin Sun1, Da Fang1, Linchao Ye1   

  1. 1.Oncology and Hepatobiliary Minimally Invasive Interventional Center,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China
  • Received:2013-05-04 Published:2013-11-01
  • Corresponding author: Jiasheng Zheng
引用本文:

李建军, 郑加生, 崔雄伟, 孙斌, 房达, 叶琳超. C形臂碘油CT在肝癌肝动脉化疗栓塞术中的应用价值[J]. 中华介入放射学电子杂志, 2013, 01(02): 32-35.

Jianjun Li, Jiasheng Zheng, Xiongwei Cui, Bin Sun, Da Fang, Linchao Ye. Application value of C-arm lipiodol CT in transhepatic arterial chemoembolization for hepatocellular carcinoma[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2013, 01(02): 32-35.

目的

探讨C形臂碘油CT在肝癌肝动脉化疗栓塞术(TACE)中的应用价值。

方法

对40例肝癌患者,先行64层CT扫描,再行TACE术。术中先行数字减影血管造影(DSA),然后注入超液态碘化油行诊断性栓塞,即刻行C形臂CT平扫,如发现有明确的肝癌病灶,再经微导管超选择插至病灶的肿瘤供养血管并注入明胶海绵颗粒栓塞。TACE术后7~14 d内复查CT(碘油CT)。由4名医师分别对64层CT、DSA、C形臂碘油CT和碘油CT的图像进行读片,并对肝癌病灶分别计数。以碘油CT的评价标准判断C形臂碘油CT的结果。TACE前后甲胎蛋白(AFP)含量比较采用配对t检验。

结果

40例患者64层CT发现13个可疑病灶;DSA确诊10个病灶,发现4个可疑病灶;C形臂碘油CT发现71个病灶;碘油CT确诊67个病灶。TACE前后的AFP值分别为(452.3±192.6)μg/L和(223.8±93.2)μg/L,差异有统计学意义(t=2.131,P=0.039)。

结论

C形臂碘油CT在TACE术中可早期发现肝癌微小病灶,使患者得到早期治疗。

Objective

To investigate the application value of C-arm lipiodol CT in transhepatic arterial chemoembolization(TACE)for hepatocellular carcinoma transhepatic arterial chemoembolization(HCC).

Methods

Totally 40 HCC patients diagnosed clinically underwent TACE after 64-slice CT.Digital substraction angiography(DSA)was firstly done then lipiodol was injected into hepatic arterial for diagnostic embolization during TACE.Then C-arm lipiodol CT was done after diagnostic embolization immediately.If HCC lesions were diagnosed,gelfoam particle was superselective injected into the tumor nourishing blood vessel through microcatheter.Lipioldol CT was performed in 7-14 days after TACE.Images acquired with 64-slice CT,DSA,C-arm lipiodol CT and lipiodol CT were retrospectively reviewed by 4 doctors.The number of detected lesions in each examination was counted respectively.Lipiodol CT images were used as the diagnostic reference for C-arm lipiodol CT.AFP was examined before and after TACE.

Results

64-slice CT detected 13 doubtful lesions,DSA detected 10 definite and 4 doubtful lesions,C-arm lipiodol CT detected 71 and lipiodol CT detected 67 definite lesions.The AFP value was(452.3±192.6)μg/L and(223.8±93.2)μg/L before and after TACE.Statistical difference was found(t=2.131,P=0.039).

Conclusions

C-arm lipiodol CT can detect micro HCC lesions early in TACE,so the patients can receive early treatment.

表1 40例肝癌患者肝动脉化疗栓塞术前血中甲胎蛋白水平正常和异常者的64层CT扫描结果
表2 40例肝癌患者肝动脉化疗栓塞术前CT扫面发现不同病灶直径的病灶数
1
Bruix J,Sala M,Llovet JM.Chemoembolization for hepatocellular carcinoma.Gastroenterology,2004,127(5 Suppl 1):S179-S188.
2
Rizvi S,Camci C,Yong Y,et al.Is post-Lipiodol CT better than i.v.contrast CT scan for early detection of HCC?A single liver transplant center experience.Transplant Proc,2006,38(9):2993-2995.
3
李建军,郑加生,崔雄伟,等.64排CT、DSA、C臂CT检出肝癌小病灶的对比.中国介入影像与治疗学,2011,8(3):236-239.
4
Nakakuma K,Tashiro S,Hiraoka T,et al.Hepatocellular carcinoma and metastatic cancer detected by iodized oil.Radiology,1985,154(1):15-17.
5
Miller DL,O'Leary TJ,Girton M.Distribution of iodized oil within the liver after hepatic arterial injection.Radiology,1987,162(3):849-851.
6
Ngan H.Lipiodol computerized tomography:how sensitive and specific is the technique in the diagnosis of hepatocellular carcinoma?Br J Radiol,1990,63(754):771-775.
7
Rampone B,Schiavone B,Martino A,et al:Current management strategy of hepatocellular carcinoma.World J Gastroenterol,2009,15(26):3210-3216.
8
Llovet JM,Burroughs A,Bruix J.Hepatocellular carcinoma.Lancet,2003,362(9399):1907-1917.
9
Takayasu K,Arii S,Ikai I,et al.Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients.Gastroenterology,2006,131(2):461-469.
10
Tam KY,Leung KC,Wang YX.Chemoembolization agents for cancer treatment.Eur J Pharm Sci,2011,44(1-2):1-10.
11
Yukisawa S,Okugawa H,Masuya Y,et al.Multidetector helical CT plus superparamagnetic iron oxide-enhanced MR imaging for focal hepatic lesions in cirrhotic liver:a comparison with multi-phase CT during hepatic arteriography.Eur J Radiol,2007,61(2):279-289.
12
Zheng XH,Guan YS,Zhou XP,et al.Detection of hypervascular hepatocellular carcinoma:comparison of multi-detector CT with digital subtraction angiography and Lipiodol CT.World J Gastroenterol 2005;11(2):200-203.
13
戴旭,韩铭钧,苏红英,等.原发性肝癌肝动脉化疗栓塞术后复发转移的分型研究.中国临床医学影像杂志,2004,15(11):613-615.
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