切换至 "中华医学电子期刊资源库"

中华介入放射学电子杂志 ›› 2018, Vol. 06 ›› Issue (02) : 133 -136. doi: 10.3877/cma.j.issn.2095-5782.2018.02.009

所属专题: 文献

专题研究·肿瘤介入

部分脾栓塞术联合TACE治疗原发性肝癌伴脾功能亢进的研究进展
张立波1, 任志忠2, 刘影2, 张跃伟2,()   
  1. 1. 563000 遵义医学院
    2. 102218 北京清华长庚医院
  • 收稿日期:2018-01-06 出版日期:2018-05-01
  • 通信作者: 张跃伟

Research progress on partial splenic embolization combined with TACE in treatment of primary hepatocellular carcinoma with hypersplenism

Libo Zhang1, Zhizhong Ren2, Ying Liu2, Yuewei Zhang2,()   

  1. 1. ZunYi Medical University, ZunYi 563000, China
    2. Beijing Tsinghua Chang Geng Hospital, Beijing 102218, China
  • Received:2018-01-06 Published:2018-05-01
  • Corresponding author: Yuewei Zhang
  • About author:
    Corresponding author: Zhang Yuewei, Email:
引用本文:

张立波, 任志忠, 刘影, 张跃伟. 部分脾栓塞术联合TACE治疗原发性肝癌伴脾功能亢进的研究进展[J]. 中华介入放射学电子杂志, 2018, 06(02): 133-136.

Libo Zhang, Zhizhong Ren, Ying Liu, Yuewei Zhang. Research progress on partial splenic embolization combined with TACE in treatment of primary hepatocellular carcinoma with hypersplenism[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2018, 06(02): 133-136.

脾功能亢进是原发性肝癌肝硬化门静脉高压的严重并发症之一,部分脾栓塞术(PSE)在治疗脾功能亢进上具有安全、有效、可重复、微创且能保留脾脏部分免疫功能等优点,已在经导管肝动脉化疗栓塞术(TACE)治疗原发性肝癌伴脾功能亢进中具有举足轻重的作用。本文主要对原发性肝癌发生脾功能亢进的机制、PSE的优势、操作方法及术后常见并发症进行综述。

Hypersplenism is a serious complication of portal hypertension in liver cirrhosis, which is a difficult problem for the treatment of this kind of patients. Partial splenic embolization (PSE) is safe, effective, reproducible, minimally invasive, and able to retain partial immune function of spleen in the treatment of hypersplenism. Transcatheter arterial chemoembolization (TACE) has played a pivotal role in the treatment of hepatocellular carcinoma with hypersplenism. The mechanism of primary hepatocellular carcinoma and hypersplenism, partial splenic embolization, operation method and postoperative complications were reviewed.

[1]
Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of Cancer in 2008 GLOBOCAN 2008[J]. Int J Cancer, 2010, 127(12):2893-2917.
[2]
Tsochatzis EA, Fatourou E, O'Beirne J, et al. Transarterial chemoembolization and bland embolization for hepatocellullar carcinoma[J]. World J Gastroenterol, 2014, 20(12):3069-3077.
[3]
杨业发,程红岩,徐爱民,等.TACE联合LPSE治疗原发性肝癌伴脾亢的临床研究[J].中华肝胆外科杂志,2003,9(3):150-153.
[4]
Abdella HM, Abd-El-Moez AT, Abu El-Maaty ME, et al. Role of partial splenic arterial embolization for hypersplenism in patients with liver cirrhosis and thrombocytopenia[J]. Indian J Gastroenterol, 2010, 29(2):59-61.
[5]
Alzen G, Basedow J, Luedemann M, et al. Partial splenic embolization as an alternative to splenectomy in hypersplenism-single center experience in 16 years[J]. Klin Padiatr, 2010, 222(6):368-373.
[6]
Maddison FE. Embolic therapy of hypersplenism[J]. Invest Radiol, 1973, 8(4):280-281.
[7]
Wirth TC. Spontaneous and therapeutic immune responses in hepatocellular carcinoma: implications for current and future immunotherapies[J]. Expert Rev Gastroenterol Hepatol, 2014, 8(1):101-110.
[8]
王素,胡继红,赵卫.部分脾栓塞术治疗肝硬化脾功能亢进的进展[J].介入放射学杂志,2014,23(6):546-549.
[9]
欧阳强,肖湘生,董伟华,等.部分性脾栓塞治疗肝癌患者脾功能亢进的疗效观察[J].介入放射学杂志,2003,12(4):273-275.
[10]
章万勇,查云飞.TACE联合部分脾栓塞术对肝癌患者免疫功能影响研究[J].临床放射学杂志,2015,34(3):451-454.
[11]
Hanafiah M, Shahizon AM, Low SF, et al. Severe thrombocytopenia due to hypersplenism treated with partial splenic embolisation[J]. BMJ Case Rep, 2013, 2013: bcr2013010163.
[12]
Elmonem SA, Tantawy HI, Ragheb AS, et al. The outcome of partial splenic embolization for hypersplenism in the cirrhotic patients[J]. The Egyptian Journal of Radiology and Nuclear Medicine, 2011, 42:35-42.
[13]
Jin GY, Lv CZ, Tang D, et al. Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism[J]. Asian Pac J Trop Med, 2016, 9(7): 702-706.
[14]
He XH, Gu JJ, Li WT, et al. Comparison of total splenic artery embolization and partial splenic embolization for hypersplenism[J]. World J Gastroenterol, 2012, 18(24):3138-3144.
[15]
惠本军,张庆桥,陈东民,等.经导管动脉化疗栓塞术联合部分性脾动脉 栓塞术治疗原发性肝癌合并脾功能亢进[J].中国介入影像与治疗学,2012,9(4):262-265.
[16]
Masada T, Tanaka T, Sakaguchi H, et al. Coils versus gelatin particles with or without intraarterial antibiotics for partial splenic embolization:a comparative evaluation[J]. J Vasc Interv Radiol, 2014, 25(6):852-858.
[17]
Matsuoka S, Kamimura S, Mizutani T, et al. Hypersplenism treated by partial splenic embolization using guglielmi detachable coils[J]. Intern Med, 2015, 54(17): 2179-2183.
[18]
Gu JJ, He XH, Li WT, et al. Safety and efficacy of splenic artery coil embolization for hypersplenism in liver cirrhosis[J]. Acta Radiol, 2012, 53(8):862-867.
[19]
Alzen G, Basedow J, Luedemann M, et al. Partial splenic embolization as an alternative to splenectomy in hypersplenism—single center experience in 16 years[J]. Klin Padiatr, 2010, 222(6):368-373.
[20]
Hadduck TA, McWilliams JP. Partial splenic artery embolization in cirrhotic patients[J]. World J Radiol, 2014, 6(5):160-168.
[21]
Smith M, Ray CE. Splenic artery embolization as an adjunctive procedure for portal hypertension[J]. Semin Intervent Radiol, 2012, 29(2):135-139.
[22]
Khurana A, Abdel Khalek M, Brown J, et al. Acute necrotizing pancreatitis following splenic artery embolization[J]. Trop Gastroenterol, 2011, 32(3):226-229.
[23]
Omer S, Zara O, Iacobescu C, et al. Partial splenic embolization for hypersplenism in cirrhotic patients. A case series[J]. J Gastrointestin Liver Dis, 2014, 23(2):215-218.
[24]
Abdella HM, Abd-El-Moez AT, Abu El-Maaty ME, et al. Role of partial splenic arterial embolization for hypersplenism in patients with liver cirrhosis and thrombocytopenia[J]. Indian J Gastroenterol, 2010, 29(2):59-61.
[25]
Ishikawa T, Kubota T, Horigome R, et al. Concurrent partial splenic embolization with transcatheter arterial chemoembolization for hepatocellular carcinoma can maintain hepatic functional reserve[J]. Hepatol Res, 2014, 44(11):1056-1061.
[1] 邹卫华, 唐勇. 腹腔镜肝癌切除术联合脾脏切除对肝癌合并脾功能亢进的早期效果分析[J]. 中华普外科手术学杂志(电子版), 2020, 14(05): 483-486.
[2] 邓骏. 全腹腔镜脾切除术联合贲门周围血管离断对脾功能亢进患者免疫功能的影响研究[J]. 中华普外科手术学杂志(电子版), 2019, 13(04): 362-365.
[3] 陈亚峰, 李江斌, 王栋, 罗年安, 臧莉, 阴继凯, 鲁建国, 董瑞. 腹腔镜脾切除术在治疗巨脾中的应用[J]. 中华腔镜外科杂志(电子版), 2021, 14(03): 152-157.
[4] 许语阳, 吕云福, 王葆春. 乙肝后肝硬化门静脉高压症脾肿大外科治疗进展[J]. 中华肝脏外科手术学电子杂志, 2023, 12(04): 469-473.
[5] 陈亚峰, 李江斌, 王栋, 鲁建国, 董瑞. 脾动脉栓塞术后远期腹腔镜巨脾切除术一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(04): 454-456.
[6] 姚志成, 黄河, 邬杰忠. 脾动脉先行的五步法腹腔镜脾切除术[J]. 中华肝脏外科手术学电子杂志, 2021, 10(01): 0-0.
[7] 鲁建国, 阴继凯, 董瑞, 王青, 王栋, 黄博, 雷世雄. 腹腔镜断流术个体化手术设计与围手术期管理[J]. 中华肝脏外科手术学电子杂志, 2019, 08(05): 388-391.
[8] 党晓卫, 张中杰, 李路豪. 门静脉高压症性脾功能亢进的处理方式选择[J]. 中华肝脏外科手术学电子杂志, 2019, 08(03): 276-280.
[9] 蒋安, 李宗芳. 脾功能亢进常见原因及治疗策略[J]. 中华肝脏外科手术学电子杂志, 2018, 07(02): 97-99.
[10] 李路豪, 党晓卫, 李林, 刘优优, 付坤坤, 牛光辉, 李松, 许培钦. 改良脾-肺固定术与断流术治疗门静脉高压症的疗效比较[J]. 中华肝脏外科手术学电子杂志, 2017, 06(04): 261-265.
[11] 王斌. 小儿实体肿瘤介入治疗进展[J]. 中华介入放射学电子杂志, 2019, 07(02): 168-171.
[12] 阳秀春, 谢鑫, 尹利平, 孙林, 龙林. 经导管肝动脉化疗栓塞术联合微波消融治疗肝癌的精准护理研究[J]. 中华介入放射学电子杂志, 2018, 06(03): 251-254.
[13] 李智, 倪才方. 经导管肝动脉化疗栓塞术的技术细节与进展[J]. 中华介入放射学电子杂志, 2018, 06(02): 127-132.
[14] 李冬玲, 尹光凤, 张淑琼, 李晓非, 李松鹏, 余婷婷. PIVKA-Ⅱ和AFP在原发性肝癌的诊断和疗效监测的临床应用[J]. 中华临床实验室管理电子杂志, 2019, 07(04): 219-222.
[15] 郭岳霖. MRI新技术在在肝癌诊断和介入术后评估的价值[J]. 中华诊断学电子杂志, 2020, 08(04): 252-252.
阅读次数
全文


摘要