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中华介入放射学电子杂志 ›› 2017, Vol. 05 ›› Issue (02) : 112 -114. doi: 10.3877/cma.j.issn.2095-5782.2017.02.013

所属专题: 文献

综述

EGFL7在肿瘤血管生成及侵袭转移中的研究进展
王运良1, 李智2,()   
  1. 1. 201506 苏州大学附属第一医院普外科
    2. 苏州大学附属第一医院介入科
  • 收稿日期:2017-03-10 出版日期:2017-05-01
  • 通信作者: 李智
  • 基金资助:
    国家自然科学基金(81501563); 江苏省青年医学人才(QNRC2016711); 苏州市科技计划(SYS201611 & KJXW2016005)

Research & development of EGFL7 in tumor angiogenesis, invasion and metastasis

Yunliang Wang1, Zhi Li2()   

  1. 1. Department of General Surgery, First Affiliated Hospital of Soochow University, Suzhou 215006, China
    2. Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
  • Received:2017-03-10 Published:2017-05-01
  • Corresponding author: Zhi Li
引用本文:

王运良, 李智. EGFL7在肿瘤血管生成及侵袭转移中的研究进展[J]. 中华介入放射学电子杂志, 2017, 05(02): 112-114.

Yunliang Wang, Zhi Li. Research & development of EGFL7 in tumor angiogenesis, invasion and metastasis[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2017, 05(02): 112-114.

血管生成和侵袭转移是肿瘤介入治疗的关键问题和难点,相关机制至今仍未阐明。表皮生长因子样结构域7(epidermal growth factor-like domain 7, EGFL7)是2003年发现的在物种间高度保守的基因,传统观点认为EGFL7特异性表达于内皮细胞,在血管生成中发挥重要作用。近年来EGFL7在肿瘤侵袭转移中的研究报道渐多,似乎发挥关键作用,并有望成为对抗侵袭转移的新靶点。本文就EGFL7在肿瘤血管生成及侵袭转移中的研究进展进行综述。

Angiogenesis, invasion and metastasis are major challenges in tumor interventional treatment. The pathogenesis mechanism has not been elucidated. Epidermal growth factor-like domain 7(EGFL7) was discovered as a highly conserved gene among species in 2003. It is believed that EGFL7 is specifically expressed in endothelial cells and plays an important role in angiogenesis. In recent research, EGFL7 has been reported to also play a role in tumor invasion and metastasis, and thus has the potential to become a new target for the design and development of novel therapeutics for tumor invasion and metastasis. This paper will review the research progress of EGFL7 in tumor angiogenesis and invasion and metastasis.

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